Endocrine Abstracts

Neuroendocrine tumours (NETs) have a unique ability to produce and secrete a variety of biogen amines and peptide hormones. They arise from multipotential stem cells, which differentiate during tumorigenesis into specific cell lines. Some of these tumours are functional, producing characteristic clinical syndromes. We present a female patient incidentally discovered to have diffuse liver metastases of neuroendocrine tumour of unknown primary origin. She was free of symptoms at...

Introduction: Hormonal syndromes are significant cause of morbidity in patients with neuroendocrine tumors (NET), requiring special treatment, rarely completely efficient. Effect on mortality is also presumed. Our aim was to investigate epidemiological characteristics of NET with hormonal production in our group of patients.Patients and methods: We analyzed 822 patients with NET of various primary tumor sites, treated at our department during period of 2...

Introduction: Women with polycystic ovary syndrome (PCOS) have numerous risk factors that lead to higher risk for cardiovascular diseases (CVD) and stroke. Measurement of carotid intima-media thickness (CIMT) is a marker of CVD.Methods: We analyzed 399 women with PCOS diagnosed using ESHRE/ASRM criteria (age: 25.5±5.1 years, BMI: 24.9±6.2 kg/m2), and 82 BMI-matched healthy controls (age 29.2±5.9 years, BMI 25.3±8.6 kg/m<sup...

IntroductionHypogonadism is a potential manifestation of many chronic diseases including cancer, presumably related to their severity. Since novel anti-cancer treatments have significantly increased survival rates of affected patients, issue of hypogonadism becomes more significant, given the importance of issues like quality of life and potential for reproduction. The aim of our study was to analyze gonadal axis function in male patients with neuroendoc...

Background: Although polycystic ovary syndrome (PCOS) constitutes a common endocrinopathy, there are several issues which confuse clinicians during everyday practice.Objective: To define the current status of knowledge of the full spectrum of PCOS among European endocrinologists.Methods: A detailed questionnaire comprising 41 items covering various aspects of diagnosis and management of women with PCOS was shared via web among memb...

Introduction: The majority of adrenocortical incidentalomas (AIs) are nonfunctional adenomas. Some of them demonstrate an autonomous cortisol secretion (ACS), a pathologic condition defined as biochemical evidence of hypercortisolism without typical signs or symptoms of Cushing’s syndrome.Subjects and methods: In this cross-sectional study, we evaluated 152 consecutive patients, aged 58.3 years (range, 25-84 years) of whom 105 (69.1%) with unilatera...

Introduction: Multiple endocrine neoplasia type 2 is an autosomal dominant polyglandular cancer syndrome. It arises as a result of a germline mutation of the RET proto-oncogene. The aim of this study was to evaluate the aggressiveness of medullary thyroid carcinoma (MTC) in patients with a proven germline mutation in codon 634 RET proto-oncogene, the occurrence of other associated diseases and survival analysis.Methods: The retrospectiv...

Introduction: Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy among women during reproductive age. PCOS cardinal manifestations include hyperandrogenism, oligo/anovulation, and/or polycystic ovarian morphology, and is closely linked to metabolic disorders such as obesity and insulin resistance (IR). It was observed that single-point insulin sensitivity estimator (SPISE) index is associated with metabolic abnormalities and could predict glucose regulation ...

Introduction: Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy among women during reproductive age. Using ESHRE/ASRM diagnosis of PCOS is considered when 2 of 3 criteria are present: polycystic ovary morphology (PCOM), oligo/anovulation (ANOV) and hyperandrogenism (HA). These criteria form four different phenotypes: A (ANOV, HA, PCOM), B (ANOV, HA), C (HA, PCOM) and D (ANOV, PCOM). Several studies have found differences in anthropometric, hormonal and meta...

Heterozygotes carrying CYP21A2 gene mutations are found in 5-10% of the general population in Mediterranean countries. Accumulating data suggest a survival advantage of this population, despite the fact that carriers of two mutations suffer from either classical or non-classical congenital adrenal hyperplasia (NC-CAH), an entity with increased mortality. In an attempt to elaborate on this issue we evaluated females of reproductive age with CYP21A2 heterozygocity (HET). We have...